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Skilled Research Fellow focused on Hematology, Transglutaminase, Immunology related research. Bringing experience in both self-directed and support research capacities. Enthusiastic about furthering field knowledge, education and publishing professional papers to raise university profile. During my BSc years, I joined research early, in addition to the basic methodological courses needed to obtain a diploma. I did my research in the Department of Botany of University of Debrecen, Faculty of Science and Technology. In addition to preparing my thesis, after I entered the Student excellence program of University of Debrecen. In this training, I became familiar with the maintenance of suspension cultures, fixation techniques for cellular systems, micro-propagation techniques, tissue culture techniques, enzyme extraction, apoptosis detecting techniques (Tunel method, Comet assay), chromatin and chromosomes labelling (Carmine acetic chromosome extraction, preparation) techniques. I continued my studies in the department, where my thesis on Biology MSc Plant Biology was " Study of the cellular and growth inhibitory effects of microcistin-LR cyanobacterial toxin in goose grass (Arabidopsis thaliana)".
Parallel I did my Biotechnology MSc Pharmaceutical Biotechnology program. My thesis was prepared at the University of Debrecen, Faculty of Medicine, Institute of Biochemistry and Molecular Biology "Study of all-trans retinoic acid and arsenic trioxide combined treatment on NB4 acute promielocytic leukaemia cell lines". I have achieved methods for maintaining human cell culturing systems , protein, DNA, and RNA isolation methods (TRISOL/column based on chromatography), cytospin preparations, protein detection (WB, SDS-PAGE), flow cytometric (FACS apoptosis/surface marker expression), densitometric evaluation, gene expression studies (PCR, RT-PCR, Real-Time qPCR). I am currently doing my research focusing on the tissue transglutaminse roles in cellular signaling, apoptosis and cell survival processes at the Institute of Biochemistry and Molecular Biology at the same department.
Czimmerer, Z., Halász, L., Dániel, B., Varga, Z., Bene, K., Domokos, A., Hoeksema, M., Shen, Z., Berger, W., Silye-Cseh, T., Jambrovics, K., Kolostyák, Z., Fenyvesi, F., Váradi, J., Póliska, S., Hajas, G., Szatmári, I., Glass, C., Bácsi, A., Nagy, L.: The epigenetic state of IL-4-polarized macrophages enables inflammatory cistromic expansion and extended synergistic response to TLR ligands. Immunity. 55 (11), 2006-2026, 2022. D1 Immunology (2021) D1 Immunology and Allergy (2021) D1 Infectious Diseases (2021)
Kenesei, Á., Volkó, J., Szalóki, N., Mocsár, G., Jambrovics, K., Balajthy, Z., Dóczy-Bodnár, A., Tóth, K., Waldmann, T., Vámosi, G.: IL-15 Trans-Presentation Is an Autonomous, Antigen-Independent Process. J. Immunol. 207 (10), 2489-2500, 2021. Q1 Immunology Q1 Immunology and Allergy
Jambrovics, K., Uray, I., Keillor, J., Fésüs, L., Balajthy, Z.: Benefits of Combined All-Trans Retinoic Acid and Arsenic Trioxide Treatment of Acute Promyelocytic Leukemia Cells and Further Enhancement by Inhibition of Atypically Expressed Transglutaminase 2. Cancers (Basel). 12 (3), 648-, 2020. Q2 Cancer Research Q1 Oncology
Volkó, J., Kenesei, Á., Zhang, M., Várnai, P., Mocsár, G., Petrus, M., Jambrovics, K., Balajthy, Z., Müller, G., Dóczy-Bodnár, A., Tóth, K., Waldmann, T., Vámosi, G.: IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti-IL-2R[alfa] therapies. Proc. Natl. Acad. Sci. U. S. A. 116 (42), 21120-21130, 2019. D1 Multidisciplinary
Jambrovics, K., Uray, I., Keresztessy, Z., Keillor, J., Fésüs, L., Balajthy, Z.: Transglutaminase 2 programs differentiating acute promyelocytic leukemia cells in all-trans retinoic acid treatment to inflammatory stage through NF-kB activation. Haematol-Hematol. J. 104 (3), 505-515, 2019. D1 Hematology
Beyer, D., Tándor, I., Kónya, Z., Bátori, R., Roszik, J., Vereb, G., Erdődi, F., Vasas, G., Mikóné Hamvas, M., Jambrovics, K., Máthé, C.: Microcystin-LR, a protein phosphatase inhibitor, induces alterations in mitotic chromatin and microtubule organization leading to the formation of micronuclei in Vicia faba. Ann. Bot. 110 (4), 797-808, 2012.
Education
Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Debrecen, H-4032 Debrecen, Egyetem tér 1, Hungary
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